Article

C1q binding to surface-bound IgG is stabilized by C1r <sub>2</sub> s <sub>2</sub> proteases

2021-02-10

Abstract excerpt

Complement is an important effector mechanism for antibody-mediated clearance of infections and tumor cells. Upon binding to target cells, the antibody’s constant (Fc) domain recruits complement component C1 to initiate a proteolytic cascade that generates lytic pores and stimulates phagocytosis. The C1 complex (C1qr 2 s 2 ) consists of the large recognition protein C1q and a heterotetramer of proteases C1r and...

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Literature Corpus work: 9cf73284-d3e9-552f-a275-166610aa581a
DOI: 10.1101/2021.02.08.430229

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