Article
Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.
Molecular cell - 7 Jul 2016
Wang Guanbo, de Jong Rob N, van den Bremer Ewald T J, Beurskens Frank J, Labrijn Aran F, Ugurlar Deniz, Gros Piet, Schuurman Janine, Parren Paul W H I, Heck Albert J R
Abstract excerpt
The classical complement pathway contributes to the natural immune defense against pathogens and tumors. IgG antibodies can assemble at the cell surface into hexamers via Fc:Fc interactions, which recruit complement component C1q and induce complement activation. Biophysical characterization of the C1:IgG complex has remained elusive primarily due to the low affinity of IgG-C1q binding. Using IgG variants that...
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