C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases.

doi:10.1073/pnas.2102787118

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Article

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2021

Zwarthoff Seline A, Widmer Kevin, Kuipers Annemarie, Strasser Jürgen, Ruyken Maartje, Aerts Piet C, de Haas Carla J C, Ugurlar Deniz, den Boer Maurits A, Vidarsson Gestur, van Strijp Jos A G, Gros Piet, Parren Paul W H I, van Kessel Kok P M, Preiner Johannes, Beurskens Frank J, Schuurman Janine, Ricklin Daniel, Rooijakkers Suzan H M

Abstract excerpt

Complement is an important effector mechanism for antibody-mediated clearance of infections and tumor cells. Upon binding to target cells, the antibody's constant (Fc) domain recruits complement component C1 to initiate a proteolytic cascade that generates lytic pores and stimulates phagocytosis. The C1 complex (C1qr2s2) consists of the large recognition protein C1q and a heterotetramer of proteases C1r and C1s...

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Identifiers

PMID: 34155115
DOI: 10.1073/pnas.2102787118
PMCID: PMC8256010

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