Article

Insights into the role of C3d dimers in B cell activation and Staphylococcal immune evasion

2020-04-23

Abstract excerpt

Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b has been well-studied, fluid-phase dimers of C3 fragments remain largely unexplored. Here we present the first X-ray crystal structures of disulphide-linked human C3d dimers and show they undergo structurally-stabilising N-terminal domain swapping when in c...

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Literature Corpus work: 3ff93861-3588-589b-b0b5-c94c7836eaa4
DOI: 10.1101/2020.04.22.054700

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