Article

Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation.

2024-03-22

Abstract excerpt

<title>Abstract</title> Antibody-dependent complement activation plays a key role in the natural human immune response to infections. Currently, the understanding of which antibody-antigen combinations drive a potent complement response on bacteria is limited. Here, we develop an antigen-agnostic approach to stain and single-cell sort human IgG memory B cells recognizing intact bacterial cells, keeping surface...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bad2836b-28c1-57e1-b09a-f3c42aa27d33
DOI: 10.21203/rs.3.rs-4106905/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation.DOI 10.21203/rs.3.rs-4106905/v1Read

The Role of Complement in Antibody Therapy for Infectious DiseasesSemantic proximity Read

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infectionSemantic proximity Read

Antibody‐mediated complement activation in pathology and protectionSemantic proximity Read

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune functionSemantic proximity Read

Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosisSemantic proximity Read

Combinatorial multimer staining and spectral flow cytometry facilitate quantification and characterization of polysaccharide-specific B cell immunitySemantic proximity Read

Complement-specific antibodies: Designing novel anti-inflammatoriesSemantic proximity Read

Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflowSemantic proximity Read

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.Semantic proximity Read

Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniaeSemantic proximity Read

Complement receptors and the shaping of the natural antibody repertoireSemantic proximity Read

Dissecting human antibody responses: useful, basic and surprising findings.Semantic proximity Read