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Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites

6 May 2013

Abstract excerpt

Complement C1q is a hexameric molecule assembled from 18 polypeptide chains of three different types encoded by three genes. This versatile recognition protein senses a wide variety of immune and nonimmune ligands, including pathogens and altered self components, and triggers the classical complement pathway through activation of its associated proteases C1r and C1s. We report a method for expression of...

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PMID: 23650384
DOI: 10.1073/pnas.1304894110

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