Article

IgG hexamers initiate acute lung injury

2024-01-27

Abstract excerpt

Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, transfusion reactions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. A previously overlooked step in complement activation by IgG antibodies has been elucidated involving interactions between IgG Fc domains that enable assembly of IgG hexamers,...

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Literature Corpus work: 513f8cdd-30ba-5fab-9be4-2a398c64e9e3
DOI: 10.1101/2024.01.24.577129

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