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A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies

21 Jun 2019

Abstract excerpt

A fundamental challenge in medical microbiology is to characterize the dynamic protein-protein interaction networks formed at the host-pathogen interface. Here, we generate a quantitative interaction map between the significant human pathogen, Streptococcus pyogenes, and proteins from human saliva and plasma obtained via complementary affinity-purification and bacterial-surface centered enrichment strategies and...

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PMID: 31227708
DOI: 10.1038/s41467-019-10583-5

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