Article

Evolutionary divergence of basal and activity-dependent exon splicing in cortical neurons

2022-12-29

Abstract excerpt

Alternative splicing of mRNA exons in mammalian neurons increases diversity of the proteome and is regulatable by signaling pathways. However, the degree of conservation of basal and signal-dependent exon usage between human neurons and those from experimental models such as mice is incompletely understood. We previously showed that cortical neuronal activity-dependent gene transcription exhibits human/mouse diffe...

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Literature Corpus work: 9cd1f111-9613-5529-90f5-4677a6bf5dde
DOI: 10.1101/2022.12.29.522197

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