Article

<i>NPEPPS</i> segmental duplication drives position effect expression of <i>TBC1D3</i> in the human brain

2026-01-15

Abstract excerpt

<h4>ABSTRACT</h4> In humans, the TBC1D3 gene family is thought to play a critical role in the expansion of the frontal cortex by promoting neuronal proliferation during brain development. This gene family shows some of the greatest structural heterozygosity (∼97%) with haplotype copy numbers ranging from 3-39 among different human haplotypes. This raises the question as to how a gene so crucial in the evolutiona...

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Literature Corpus work: ab4c3d03-11b6-5952-b3db-689e0cb235bf
DOI: 10.64898/2026.01.14.699559

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