Article

Predominant Patterns of Splicing Evolution on Human, Chimpanzee, and Macaque Evolutionary Lineages

2017-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Although splicing is widespread and evolves rapidly among species, the mechanisms driving this evolution, as well as its functional implications, are not yet fully understood. We analyzed the evolution of splicing patterns based on transcriptome data from five tissues of humans, chimpanzees, rhesus macaques, and mice. In total, 1,526 exons and exon sets from 1,236 genes showed significant splici...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf83013c-ce15-5726-9cef-84d4d347d880
DOI: 10.1101/204255

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predominant Patterns of Splicing Evolution on Human, Chimpanzee, and Macaque Evolutionary LineagesDOI 10.1101/204255Read

Evolution of alternative splicing in primate brain transcriptomes.Semantic proximity Read

The "alternative" choice of constitutive exons throughout evolution.Semantic proximity Read

The splice of life: how alternative splicing shapes regulatory and phenotypic evolution.Semantic proximity Read

Cross-tissue isoform switches by human transcription factors suggest a widespread regulatory mechanismSemantic proximity Read

The evolutionary landscape of alternative splicing in vertebrate species.Semantic proximity Read

Global analysis of alternative splicing differences between humans and chimpanzees.Semantic proximity Read

Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law.Semantic proximity Read

Thousands of exon skipping events differentiate among splicing patterns in sixteen human tissuesSemantic proximity Read

Functionality of intergenic transcription: an evolutionary comparison.Semantic proximity Read

<i>SpliceImpactR</i> maps alternative RNA processing events driving protein functional diversitySemantic proximity Read

A genomic view of alternative splicing.Semantic proximity Read

Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons.Semantic proximity Read