Back to search

Article

Immune mechanisms of type 1 diabetes revealed by single-cell transcriptomics, bulk transcriptomics, and experimental validation

2024-12-17

Abstract excerpt

<h4>Background:</h4> Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing pancreatic β cells. Understanding the immune mechanisms underlying T1D is crucial for developing effective diagnostic and therapeutic strategies. This study aimed to elucidate the immune mechanisms of T1D by integrating single-cell RNA sequencing (scRNA-seq), bulk RNA-seq, and experimental va...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
159a0bd0-4208-54ae-b6bb-9fa4a4133864
DOI
10.1101/2024.12.12.628291
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Immune mechanisms of type 1 diabetes revealed by single-cell transcriptomics, bulk transcriptomics, and experimental validationDOI 10.1101/2024.12.12.628291
Single-cell RNA sequencing of peripheral blood mononuclear cells reveals complex cellular signalling signatures of metformin treatment type 2 diabetes mellitusSemantic proximity
Single-cell RNA sequencing reveals the dysfunctional characteristics of PBMCs in patients with type 2 diabetes mellitusSemantic proximity
Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetesSemantic proximity
Analysis of immune cell components and immune-related gene expression profiles in peripheral blood of patients with type 1 diabetes mellitusSemantic proximity
Deciphering the Transcriptomic Landscape of Type 2 Diabetes: Insights from Bulk RNA Sequencing and Single-Cell AnalysisSemantic proximity
Single-cell RNA sequencing and transcriptomic analysis reveal the critical signatures involved in nonhealing diabetic foot ulcersSemantic proximity
A surviving beta cell subpopulation enriched in patients with T1DSemantic proximity
An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signalsSemantic proximity
Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetesSemantic proximity
Single-cell and pseudobulk transcriptomic profiling reveals immune-enriched disease- associated signatures in human pancreatic islets from type 2 diabetesSemantic proximity
Multitissue Multiomics Integration Reveals Tissue-Specific Pathways, Gene Networks, and Drug Candidates for Type 1 DiabetesSemantic proximity
Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learningSemantic proximity
Select a neighboring publication to make it the new centre.