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Article

A Biologically-validated HCV E1E2 Heterodimer Structural Model.

Scientific reports - 16 Mar 2017

Castelli Matteo, Clementi Nicola, Pfaff Jennifer, Sautto Giuseppe A, Diotti Roberta A, Burioni Roberto, Doranz Benjamin J, Dal Peraro Matteo, Clementi Massimo, Mancini Nicasio

Abstract excerpt

The design of vaccine strategies and the development of drugs targeting the early stages of Hepatitis C virus (HCV) infection are hampered by the lack of structural information about its surface glycoproteins E1 and E2, the two constituents of HCV entry machinery. Despite the recent crystal resolution of limited versions of both proteins in truncated form, a complete picture of the E1E2 complex is still missing....

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Identifiers

PMID: 28303031
DOI: 10.1038/s41598-017-00320-7
PMCID: PMC5428263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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