Article

Rational design of next-generation filovirus vaccines through glycoprotein stabilization, nanoparticle display, and glycan modification

2025-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Filoviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive. Here, we evaluate a general strategy for stabilizing glycoprotein (GP) structures from Ebola, Sudan, and Bundibugyo orthoebolaviruses and Ravn orthomarburgvirus. A 3.2 Å crysta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4e6d9a5-9c91-56e5-a41f-ef135f5fb337
DOI: 10.1101/2025.03.02.641072

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rational design of next-generation filovirus vaccines through glycoprotein stabilization, nanoparticle display, and glycan modificationDOI 10.1101/2025.03.02.641072Read

Design of universal Ebola virus vaccine candidates <i>via</i> immunofocusingSemantic proximity Read

Design of universal Ebola virus vaccine candidates via immunofocusingSemantic proximity Read

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccinesSemantic proximity Read

Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1Semantic proximity Read

Generation and Selection of a Panel of Pan-Filovirus Single-Chain Antibodies using Cell-Free Ribosome DisplaySemantic proximity Read

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalkSemantic proximity Read

Structure and design of Langya virus glycoprotein antigensSemantic proximity Read

Convergence of a common solution to broad ebolavirus neutralization by glycan cap directed human antibodiesSemantic proximity Read

Virus-like particles: flexible platforms for vaccine developmentSemantic proximity Read

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of VulnerabilitySemantic proximity Read

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2Semantic proximity Read

Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccinesSemantic proximity Read