Article

Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation

2025-02-19

Abstract excerpt

<h4>ABSTRACT</h4> HNRNPU is an RNA-binding protein with diverse roles in transcriptional and post-transcriptional regulation. Pathogenic genetic variants of HNRNPU cause a severe neurodevelopmental disorder (NDD), but the underlying molecular mechanisms are unclear. Here, we comprehensively investigate the HNRNPU molecular interactome by integrating protein-protein interaction (PPI) mapping, RNA target identifica...

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Literature Corpus work: f800cf78-54dd-507c-9b6f-21e00ec88f0e
DOI: 10.1101/2025.02.19.638869

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