Article

High-throughput mapping of 6,888 <i>RAD51D</i> variants identifies distinct biochemical functions needed for homologous recombination and olaparib response

2026-01-11

Abstract excerpt

<h4>Summary</h4> The tumor suppressor RAD51D is essential for homologous recombination (HR). Pathogenic variants in RAD51D are associated with breast and ovarian cancers. However, most clinical missense variants are of unknown significance. We performed a multiplex assay of variant effect to test 6,888 RAD51D coding variants for loss-of-function. The resulting variant-to-function map perfectly separates known...

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Literature Corpus work: 9c7bfc76-a55c-5dee-a8d2-d7a70ecd08d4
DOI: 10.64898/2026.01.11.698865

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