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A decade of RAD51C and RAD51D germline variants in cancer.

Human mutation - 1 Mar 2022

Boni Jacopo, Idani Aida, Roca Carla, Feliubadaló Lidia, Tomiak Eva, Weber Evan, Foulkes William D, Orthwein Alexandre, El Haffaf Zaki, Lazaro Conxi, Rivera Barbara

Abstract excerpt

Defects in DNA repair genes have been extensively associated with cancer susceptibility. Germline pathogenic variants (GPV) in genes involved in homologous recombination repair pathways predispose to cancers arising mainly in the breast and ovary, but also other tissues. The RAD51 paralogs RAD51C and RAD51D were included in this group 10 years ago when germline variants were associated with non-BRCA1/2 familial...

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Identifiers

PMID: 34923718
DOI: 10.1002/humu.24319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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