Article

A decade of RAD51C/D: Germline pathogenic variants and their phenotypic landscape

2021-09-25

Abstract excerpt

Defects in DNA repair genes have been extensively associated to cancer susceptibility. Germline pathogenic variants (GPV) in genes involved in homologous recombination repair pathway predispose to cancers arising mainly in breast and ovary, but also other tissues. The RAD51 paralogs RAD51C and RAD51D were included in this group 10 years ago, when germline variants were associated to non-BRCA1/2 familial ovarian ca...

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Literature Corpus work: 6917ae0a-659b-589e-ba6a-46885646cae0
DOI: 10.22541/au.163253770.09513513/v1

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