Article
Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions.
Nature communications - 16 Jul 2025
Rein Hayley L, Rawal Yashpal, Palovcak-Lightbourn Anna L, Ganesan Gayatri S, Parker Phoebe S, Russell Reagan, Darrah Kristie E, Afsar Mohammad, Sullivan Meghan R, Hengel Sarah R, Radke Marc R, Opresko Patricia L, Yanowitz Judith L, Greene Eric C, Lee Jung-Min, Domchek Susan M, Swisher Elizabeth M, Olsen Shaun K, Sung Patrick, Bernstein Kara A
Abstract excerpt
RAD51C is a tumor suppressor gene with over 285 variants of unknown significance (VUS) found in primary ovarian tumors. RAD51C is a paralog of the recombinase RAD51, and it forms complexes with other paralogs to regulate RAD51 activity. We screened 27 ovarian cancer-derived RAD51C VUS to identify those that affect the assembly of functional tetrameric RAD51B-C-D-XRCC2 (BCDX2) complex. With yeast 3-hybrid and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.