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Article

Finding significance: New perspectives in variant classification of the RAD51 regulators, BRCA2 and beyond.

DNA repair - 1 Oct 2023

Rein Hayley L, Bernstein Kara A

Abstract excerpt

For many individuals harboring a variant of uncertain functional significance (VUS) in a homologous recombination (HR) gene, their risk of developing breast and ovarian cancer is unknown. Integral to the process of HR are BRCA1 and regulators of the central HR protein, RAD51, including BRCA2, PALB2, RAD51C and RAD51D. Due to advancements in sequencing technology and the continued expansion of cancer screening...

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Identifiers

PMID: 37651978
DOI: 10.1016/j.dnarep.2023.103563
PMCID: PMC10529980

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