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Article

Joint genetic analysis using variant sets reveals polygenic gene-context interactions.

PLoS genetics - 1 Apr 2017

Casale Francesco Paolo, Horta Danilo, Rakitsch Barbara, Stegle Oliver

Abstract excerpt

Joint genetic models for multiple traits have helped to enhance association analyses. Most existing multi-trait models have been designed to increase power for detecting associations, whereas the analysis of interactions has received considerably less attention. Here, we propose iSet, a method based on linear mixed models to test for interactions between sets of variants and environmental states or other...

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Identifiers

PMID: 28426829
DOI: 10.1371/journal.pgen.1006693
PMCID: PMC5398484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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