Article

Computational design of CYP102A1 variants for the biosynthesis of a next-generation antiplatelet drug DT-678

2025-12-05

Abstract excerpt

Clopidogrel is a widely used antiplatelet prodrug to treat acute coronary syndromes. However, its clinical efficacy is hampered by ineffective bioactivation to produce the pharmacologically active metabolite (AM), leading to variability in antiplatelet response among different ethnic groups. To overcome the shortcomings of clopidogrel, DT-678 was developed by conjugating the AM to 3-nitropyridine-2-thiol via a mix...

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Literature Corpus work: 9c5f0de6-a41b-5426-a0d1-d30ede998602
DOI: 10.64898/2025.12.04.692440

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Computational design of CYP102A1 variants for the biosynthesis of a next-generation antiplatelet drug DT-678DOI 10.64898/2025.12.04.692440Read

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