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Article

Switching glycosyltransferase UGTBL1 regioselectivity toward polydatin synthesis using a semi-rational design.

Organic & biomolecular chemistry - 4 Apr 2018

Fan Bo, Dong Wenxin, Chen Tianyi, Chu Jianlin, He Bingfang

Abstract excerpt

The 62nd residue of glycosyltransferase UGTBL1 was identified as a "hotspot" for glycosylation at 3-OH of resveratrol. Via semi-rational design including structure-guided alanine scanning and saturation mutations, the mutation I62G significantly switched the regioselectivity from 4'-OH to 3-OH of resveratrol and mainly produced polydatin (87.7%), a therapeutic natural product.

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Identifiers

PMID: 29561022
DOI: 10.1039/C8OB00376A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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