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Article

Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene.

Oncotarget - 28 Feb 2014

Hoivik Erling A, Kusonmano Kanthida, Halle Mari K, Berg Anna, Wik Elisabeth, Werner Henrica M J, Petersen Kjell, Oyan Anne M, Kalland Karl-Henning, Krakstad Camilla, Trovik Jone, Widschwendter Martin, Salvesen Helga B

Abstract excerpt

Cancers arise through accumulating genetic and epigenetic alterations, considered relevant for phenotype and approaches to targeting new therapies. We investigated a unique collection of endometrial cancer precursor samples and clinically annotated primary and metastatic lesions for two evolutionary and functionally related transcription factors, CCCTC-binding factor (zinc finger protein) (CTCF) and its paralogue...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Endometrioid
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to DNA-Binding Proteins

Share to DNA Methylation

Share to Endometrial Neoplasms

Share to Epigenesis, Genetic

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 24658009
DOI: 10.18632/oncotarget.1697
PMCID: PMC4011582

Genes

CTCFL
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene.PMID 24658009Read ↗

The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancerSemantic proximity Read ↗

The epigenetic factor BORIS (CTCFL) controls the androgen receptor regulatory network in ovarian cancerSemantic proximity Read ↗

The CTCF Paralog BORIS Contributes to the Ovarian Cancer Transcriptional Program by Relaxing CTCF-mediated 3D Genome OrganizationSemantic proximity Read ↗

BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumoursSemantic proximity Read ↗

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibilitySemantic proximity Read ↗

CTCF and BORIS in genome regulation and cancerSemantic proximity Read ↗

CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <i>H19</i> Differentially Methylated RegionSemantic proximity Read ↗

PAX2 is Transcriptionally Silenced by a Distinct Mechanism of Epigenetic Reprogramming to Initiate Endometrial CarcinogenesisSemantic proximity Read ↗

Attenuated APC contributes to FGF12 expression and EC progression with an integrated multi-omics analysisSemantic proximity Read ↗

Conditional Expression of the CTCF-Paralogous Transcriptional Factor BORIS in Normal Cells Results in Demethylation and Derepression of MAGE-A1 and Reactivation of Other Cancer-Testis GenesSemantic proximity Read ↗

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers.Semantic proximity Read ↗

Functionally Coherent Transcription Factor Target Networks Illuminate Control of Epithelial RemodellingSemantic proximity Read ↗

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