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Article

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites

31 Jan 2024

Abstract excerpt

BACKGROUND: Pervasive usage of alternative promoters leads to the deregulation of gene expression in carcinogenesis and may drive the emergence of new genes in spermatogenesis. However, little is known regarding the mechanisms underpinning the activation of alternative promoters. RESULTS: Here we describe how alternative cancer-testis-specific transcription is activated. We show that intergenic and intronic CTCF...

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PMID: 38297316
DOI: 10.1186/s13059-024-03175-0

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