Article

Profiling <i>APOL1</i> Nephropathy Risk Variants in Genome-Edited Kidney Organoids with Single-Cell Transcriptomics

2019-09-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> DNA variants in APOL1 associate with kidney disease, but the pathophysiological mechanisms remain incompletely understood. Model organisms lack the APOL1 gene, limiting the degree to which disease states can be recapitulated. Here we present single-cell RNA sequencing (scRNA-seq) of genome-edited human kidney organoids as a platform for profiling effects of APOL1 risk var...

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Literature Corpus work: 9c1c3752-659f-5fe3-aecd-4f620f82e960
DOI: 10.1101/780684

Open publication

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