Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOL1 promotes endothelial cell activation beyond the glomerulus

8 May 2023

Abstract excerpt

Apolipoprotein L1 (APOL1) high-risk genotypes are associated with increased risk of chronic kidney disease (CKD) in people of West African ancestry. Given the importance of endothelial cells (ECs) in CKD, we hypothesized that APOL1 high-risk genotypes may contribute to disease via EC-intrinsic activation and dysfunction. Single cell RNA sequencing (scRNA-seq) analysis of the Kidney Precision Medicine Project...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Kidney Disease and Diabetes
Share to Renal and related cancers
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37250770
DOI: 10.1016/j.isci.2023.106830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOL1 promotes endothelial cell activation beyond the glomerulusPMID 37250770Read ↗

The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.Semantic proximity Read ↗

Analysis of Glomerular Transcriptomes from Nephrotic Patients Suggest<i>APOL1</i>Risk Variants Impact Parietal Epithelial CellsSemantic proximity Read ↗

Clinical and Genetic Characteristics of CKD Patients with High-Risk APOL1 Genotypes.Semantic proximity Read ↗

Profiling APOL1 Nephropathy Risk Variants in Genome-Edited Kidney Organoids with Single-Cell TranscriptomicsSemantic proximity Read ↗

Molecular Mechanisms of APOL1-Associated Kidney Disease.Semantic proximity Read ↗

A glomerular transcriptomic landscape of <i>APOL1</i> in Black patients with focal segmental glomerulosclerosisSemantic proximity Read ↗

Epigenetic associations with kidney disease in individuals of African ancestry with APOL1 high-risk genotypes and HIV.Semantic proximity Read ↗

Profiling <i>APOL1</i> Nephropathy Risk Variants in Genome-Edited Kidney Organoids with Single-Cell TranscriptomicsSemantic proximity Read ↗

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes.Semantic proximity Read ↗

Apolipoprotein L1 and Kidney Disease in African Americans.Semantic proximity Read ↗

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.Semantic proximity Read ↗

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.