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Article

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2016

Krupkin Miri, Wekselman Itai, Matzov Donna, Eyal Zohar, Diskin Posner Yael, Rozenberg Haim, Zimmerman Ella, Bashan Anat, Yonath Ada

Abstract excerpt

Two structurally unique ribosomal antibiotics belonging to the orthosomycin family, avilamycin and evernimicin, possess activity against Enterococci, Staphylococci, and Streptococci, and other Gram-positive bacteria. Here, we describe the high-resolution crystal structures of the eubacterial large ribosomal subunit in complex with them. Their extended binding sites span the A-tRNA entrance corridor, thus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27791159
DOI: 10.1073/pnas.1614297113
PMCID: PMC5098648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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