Article
Macrolide antibiotic interaction and resistance on the bacterial ribosome.
Current opinion in investigational drugs (London, England : 2000) - 1 Feb 2003
Poehlsgaard Jacob, Douthwaite Stephen
Abstract excerpt
Our understanding of the fine structure of many antibiotic target sites has reached a new level of enlightenment in the last couple of years due to the advent, by X-ray crystallography, of high-resolution structures of the bacterial ribosome. Many classes of clinically useful antibiotics bind to the ribosome to inhibit bacterial protein synthesis. Macrolide, lincosamide and streptogramin B (MLSB) antibiotics form...
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