Article

The MIR-NAT <i>MAPT-AS1</i> does not regulate Tau expression in human neurons

2023-01-27

Abstract excerpt

The MAPT gene encodes Tau protein, a member of the large family of microtubule-associated proteins. Tau forms large insoluble aggregates that are toxic to neurons in several neurological disorders and neurofibrillary Tau tangles represent a key pathological hallmark of Alzheimer’s disease (AD) and other ‘tauopathies’ 1,2 . Several Tau-lowering strategies are being investigated as a potential treatment for AD but...

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Literature Corpus work: 9bf19ee4-25b4-5b2a-acd0-089ed5acf92d
DOI: 10.1101/2023.01.27.525631

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