Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The human MAPT locus generates circular RNAs.

Biochimica et biophysica acta. Molecular basis of disease - 1 Sept 2018

Welden Justin R, van Doorn Jacob, Nelson Peter T, Stamm Stefan

Abstract excerpt

The microtubule-associated protein Tau, generated by the MAPT gene is involved in dozens of neurodegenerative conditions ("tauopathies"), including Alzheimer's disease (AD) and frontotemporal lobar degeneration/frontotemporal dementia (FTLD/FTD). The pre-mRNA of MAPT is well studied and its aberrant pre-mRNA splicing is associated with frontotemporal dementia. Using a PCR screen of RNA from human brain tissues,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Frontotemporal Dementia
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Circular

Share to RNA Precursors

Share to tau Proteins

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 29729314
DOI: 10.1016/j.bbadis.2018.04.023
PMCID: PMC6434521

Genes

MAPT
CLK2
SRSF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The human MAPT locus generates circular RNAs.PMID 29729314Read ↗

Circular RNAs from the MAPT and TARDP Genes: Novel Players in Neurodegeneration?Semantic proximity Read ↗

Influence of FTDP-17 mutants on circular Tau RNAsSemantic proximity Read ↗

Influence of FTDP-17 mutants on circular tau RNAs.Semantic proximity Read ↗

What’s in a Gene? The Outstanding Diversity of MAPTSemantic proximity Read ↗

Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3Semantic proximity Read ↗

Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer’s disease and progressive supranuclear palsy brainsSemantic proximity Read ↗

Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expressionSemantic proximity Read ↗

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing.Semantic proximity Read ↗

Assessing circular RNAs in Alzheimer diseaseSemantic proximity Read ↗

Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expressionSemantic proximity Read ↗

m6A-dependent circular RNA formation mediates tau-induced neurotoxicitySemantic proximity Read ↗

Finding MAPT Mutations in Frontotemporal Dementia and Other Tauopathies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.