Loss of CD44 re-educates pancreatic cancer-associated fibroblasts modulating their fibrotic and immunosuppressive functions

Abstract excerpt

Pancreatic tumors are characterized by a prominent stroma that makes up to 90% of the tumor. Due to the significant upregulation of CD44, a family of transmembrane glycoproteins, in pancreatic cancer-associated fibroblasts (CAFs), we investigated its role in myofibroblastic and inflammatory CAF subsets. Conditional deletion of Cd44 in CAFs in Cd44 fl/fl ;PdgfrβCreER T2 mice, significantly decreased the tumor v...

Topics

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• Cancer-Associated Fibroblasts
• Carcinoma, Pancreatic Ductal
• CD8-Positive T-Lymphocytes
• MAP Kinase Signaling System
• Myofibroblasts
• Pancreatic and Hepatic Oncology Research
• Single-Cell Analysis
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

9be9b4df-3b87-5151-a313-b7e1de59a0e3

DOI

10.64898/2025.12.05.692606