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Cancer‐associated fibroblasts that restrain cancer progression: Hypotheses and perspectives

15 Feb 2020

Abstract excerpt

The roles of cancer-associated fibroblasts (CAF) in the progression of various types of cancers are well established. CAF promote cancer progression through pleiotropic mechanisms, including the secretion of soluble factors and extracellular matrix, physical interactions with cancer cells, and the regulation of angiogenesis, immunity and metabolism. Their contribution to therapeutic resistance is also well...

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PMID: 32060987
DOI: 10.1111/cas.14346

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