Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer.

doi:10.1038/s41467-024-54975-8

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Article

Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer.

Nature communications - 3 Dec 2024

Veghini Lisa, Pasini Davide, Fang Rui, Delfino Pietro, Filippini Dea, Neander Christian, Vicentini Caterina, Fiorini Elena, Lupo Francesca, D'Agosto Sabrina L, Carbone Carmine, Agostini Antonio, Piro Geny, Rosa Diego, Bevere Michele, Markus Peter, Behrens Diana, Luchini Claudio, Lawlor Rita T, Scarpa Aldo, Biffi Giulia, Cheung Phyllis F, Siveke Jens T, Corbo Vincenzo

Abstract excerpt

Fibroblast heterogeneity is increasingly recognised across cancer conditions. Given their important contribution to disease progression, mapping fibroblasts' heterogeneity is critical to devise effective anti-cancer therapies. Cancer-associated fibroblasts (CAFs) represent the most abundant cell population in pancreatic ductal adenocarcinoma (PDAC). Whether CAF phenotypes are differently specified by PDAC cell...

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PMID: 39627211
DOI: 10.1038/s41467-024-54975-8
PMCID: PMC11615044

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