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Targeting Cancer‐Associated Fibroblasts: Eliminate or Reprogram?

2 Jan 2025

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME). Given their various roles in tumor progression and treatment resistance, CAFs are promising therapeutic targets in cancer. The elimination of tumor-promoting CAFs has been investigated in various animal models to determine whether it effectively suppresses tumor growth. Based on recent evidence, several simple strategies...

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PMID: 39745128
DOI: 10.1111/cas.16443

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