Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2020

Awaji Mohammad, Saxena Sugandha, Wu Lingyun, Prajapati Dipakkumar R, Purohit Abhilasha, Varney Michelle L, Kumar Sushil, Rachagani Satyanarayana, Ly Quan P, Jain Maneesh, Batra Surinder K, Singh Rakesh K

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies. Desmoplasia and tumor-supporting inflammation are hallmarks of PDAC. The tumor microenvironment contributes significantly to tumor progression and spread. Cancer-associated fibroblasts (CAFs) facilitate therapy resistance and metastasis. Recent reports emphasized the concurrence of multiple subtypes of CAFs with diverse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cancer-Associated Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Pancreatic Ductal

Share to Gene Expression Regulation, Neoplastic

Share to Pancreatic Neoplasms

Share to Receptors, Interleukin-8B

Share to Tumor Cells, Cultured

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 32453916
DOI: 10.1096/fj.201902990R
PMCID: PMC7501205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma.PMID 32453916Read ↗

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.Semantic proximity Read ↗

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancerSemantic proximity Read ↗

The role of microRNAs in the modulation of cancer-associated fibroblasts activity during pancreatic cancer pathogenesisSemantic proximity Read ↗

CXCR2 signaling regulates KRAS(G¹²D)-induced autocrine growth of pancreatic cancer.Semantic proximity Read ↗

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer GrowthSemantic proximity Read ↗

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDACSemantic proximity Read ↗

circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway.Semantic proximity Read ↗

Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Pancreatic Fibroblast Heterogeneity: From Development to CancerSemantic proximity Read ↗

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogrammingSemantic proximity Read ↗

Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.