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Article

Derepression of <i>hTERT</i> gene expression promotes escape from oncogene-induced cellular senescence

8 Aug 2016

Abstract excerpt

Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that restrains cancer progression at premalignant stages, in part by causing telomere dysfunction. Currently it is unknown whether this proliferative arrest presents a stable and therefore irreversible barrier to cancer progression. Here we demonstrate that cells frequently escape OIS induced by oncogenic H-Ras and B-Raf, after a...

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Share to Advanced biosensing and bioanalysis techniques
Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence

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PMID: 27503890
DOI: 10.1073/pnas.1602379113

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