A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.

doi:10.1016/j.molcel.2021.10.017

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Article

A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.

Molecular cell - 2 Dec 2021

Zampetidis Christos P, Galanos Panagiotis, Angelopoulou Andriani, Zhu Yajie, Polyzou Aikaterini, Karamitros Timokratis, Kotsinas Athanassios, Lagopati Nefeli, Mourkioti Ioanna, Mirzazadeh Reza, Polyzos Alexandros, Garnerone Silvano, Mizi Athanasia, Gusmao Eduardo G, Sofiadis Konstantinos, Gál Zita, Larsen Dorthe H, Pefani Dafni-Eleftheria, Demaria Marco, Tsirigos Aristotelis, Crosetto Nicola, Maya-Mendoza Apolinar, Papaspyropoulos Angelos, Evangelou Konstantinos, Bartek Jiri, Papantonis Argyris, Gorgoulis Vassilis G

Abstract excerpt

Oncogene-induced senescence (OIS) is an inherent and important tumor suppressor mechanism. However, if not removed timely via immune surveillance, senescent cells also have detrimental effects. Although this has mostly been attributed to the senescence-associated secretory phenotype (SASP) of these cells, we recently proposed that "escape" from the senescent state is another unfavorable outcome. The mechanism...

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PMID: 34793711
DOI: 10.1016/j.molcel.2021.10.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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