Article

TLR4 promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis by a mechanism independent of hepatocytes and inflammatory cells

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> In metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis is the most important prognostic factor, and fibrosis can lead to hepatic cirrhosis and cancer. In the liver toll-like receptor 4 (TLR4) signaling promotes fibrosis. To investigate the role of TLR4 in the development of MASLD, we used a mouse model of MASLD, and we deleted the Tlr4 gene either in the whole body...

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Literature Corpus work: 6acf4751-b33d-549b-8bb5-b4ba65dcf698
DOI: 10.1101/2025.09.25.678670

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