Article

Hepatocyte-specific deletion of <i>Pparα</i> promotes NASH in the context of obesity

2018-12-06

Abstract excerpt

<h4>Objectives</h4> Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lacking Pparα in hepatocytes spontaneously develop steatosis without obesity in aging. Altough steatosis is a benign condition it can develop into non alcoholic steatohepatitis (NASH),...

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Literature Corpus work: 99bcfc4c-90c9-5720-8abc-ae7f0685fce9
DOI: 10.1101/488031

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