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Article

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

8 Jan 2016

Abstract excerpt

Transforming growth factor-beta1 (TGF-β1), a key member in the TGF-β superfamily, plays a critical role in the development of hepatic fibrosis. Its expression is consistently elevated in affected organs, which correlates with increased extracellular matrix deposition. SMAD proteins have been studied extensively as pivotal intracellular effectors of TGF-β1, acting as transcription factors. In the context of...

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PMID: 26747705
DOI: 10.1369/0022155415627681

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