Article

Mutated SF3B1 is associated with transcript isoform changes of the genes UQCC and RPL31 both in CLLs and uveal melanomas

2013-12-02

Abstract excerpt

<h4>Background</h4> Genome sequencing studies of chronic lympoid leukemia (CLL) have provided a comprehensive overview of recurrent somatic mutations in coding genes. One of the most intriguing discoveries has been the prevalence of mutations in the HEAT-repeat domain of the splicing factor SF3B1 . A frequently observed variant is predicted to cause the substitution of a lysine with a glutamic acid at position 7...

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Literature Corpus work: 9ba0bee9-5d2c-57da-883d-4f474b6314a1
DOI: 10.1101/000992

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