Article

Chemokine Receptor 1 and its associated immune pathway are downregulated in SF3B1 <sup>MT</sup> blood and non-blood cancers

2022-03-31

Abstract excerpt

Mutation of the essential splicing factor SF3B1 is primarily associated with hematological cancers but also occurs in solid tumors. We edited the most common mutation, K700E, into human embryonic stem (ES) cells to determine the effects of this mutation alone in an undifferentiated/non-cancer background. Unexpectedly, >20% of the significantly upregulated genes in the SF3B1 K700E ES lines have immune functions. T...

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Literature Corpus work: 057923e7-7c17-55a1-af18-77b6de687153
DOI: 10.1101/2022.03.31.485699

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Chemokine Receptor 1 and its associated immune pathway are downregulated in SF3B1 <sup>MT</sup> blood and non-blood cancersDOI 10.1101/2022.03.31.485699Read

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