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Article

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.

The New England journal of medicine - 29 Dec 2011

Wang Lili, Lawrence Michael S, Wan Youzhong, Stojanov Petar, Sougnez Carrie, Stevenson Kristen, Werner Lillian, Sivachenko Andrey, DeLuca David S, Zhang Li, Zhang Wandi, Vartanov Alexander R, Fernandes Stacey M, Goldstein Natalie R, Folco Eric G, Cibulskis Kristian, Tesar Bethany, Sievers Quinlan L, Shefler Erica, Gabriel Stacey, Hacohen Nir, Reed Robin, Meyerson Matthew, Golub Todd R, Lander Eric S, Neuberg Donna, Brown Jennifer R, Getz Gad, Wu Catherine J

Abstract excerpt

BACKGROUND: The somatic genetic basis of chronic lymphocytic leukemia, a common and clinically heterogeneous leukemia occurring in adults, remains poorly understood. METHODS: We obtained DNA samples from leukemia cells in 91 patients with chronic lymphocytic leukemia and performed massively parallel sequencing of 88 whole exomes and whole genomes, together with sequencing of matched germline DNA, to characterize...

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Topics

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Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

Share to DNA, Neoplasm

Share to Gene Library

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to RNA Splicing

Share to Spliceosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 22150006
DOI: 10.1056/NEJMoa1109016
PMCID: PMC3685413

Genes

ATM
MAPK1
MYD88
NOTCH1
ZMYM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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