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Article

Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms.

Blood - 10 Jan 2013

Cazzola Mario, Rossi Marianna, Malcovati Luca

Abstract excerpt

Precursor mRNA splicing is catalyzed by the spliceosome, a macromolecule composed of small nuclear RNAs associated with proteins. The SF3B1 gene encodes subunit 1 of the splicing factor 3b, which is important for anchoring the spliceosome to precursor mRNA. In 2011, whole-exome sequencing studies showed recurrent somatic mutations of SF3B1 and other genes of the RNA splicing machinery in patients with...

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Identifiers

PMID: 23160465
DOI: 10.1182/blood-2012-09-399725
PMCID: PMC3790951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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