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Article

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness.

Blood - 22 Dec 2011

Rossi Davide, Bruscaggin Alessio, Spina Valeria, Rasi Silvia, Khiabanian Hossein, Messina Monica, Fangazio Marco, Vaisitti Tiziana, Monti Sara, Chiaretti Sabina, Guarini Anna, Del Giudice Ilaria, Cerri Michaela, Cresta Stefania, Deambrogi Clara, Gargiulo Ernesto, Gattei Valter, Forconi Francesco, Bertoni Francesco, Deaglio Silvia, Rabadan Raul, Pasqualucci Laura, Foà Robin, Dalla-Favera Riccardo, Gaidano Gianluca

Abstract excerpt

The genetic lesions identified in chronic lymphocytic leukemia (CLL) do not entirely recapitulate the disease pathogenesis and the development of serious complications, such as chemorefractoriness. While investigating the coding genome of fludarabine-refractory CLL, we observed that mutations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 22039264
DOI: 10.1182/blood-2011-08-373159
PMCID: PMC3245210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22039264-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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