Article

Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across 5 fly Parkinsonism models

2023-03-11

Abstract excerpt

The classical diagnosis of Parkinsonism is based on motor symptoms that are the consequence of nigrostriatal pathway dysfunction and reduced dopaminergic output. However, a decade prior to the emergence of motor issues, patients frequently experience non-motor symptoms, such as a reduced sense of smell (hyposmia). The cellular and molecular bases for these early defects remain enigmatic. To explore this, we develo...

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Literature Corpus work: 34d777e0-cd06-5d19-9b49-4b4a5f8be87a
DOI: 10.1101/2023.03.11.532176

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