Article

Impaired neurogenesis and synaptogenesis in iPSC-derived Parkinson’s patient cortical neurons with D620N VPS35 mutation

2024-08-09

Abstract excerpt

Presynaptic dysfunction is an important early process in the pathophysiology of Parkinson’s disease (PD) that drives disease progression. To gain insight into the intrinsic synapse impairment in PD, we performed comprehensive electrophysiological and morphological analysis of iPSC-derived cortical neurons derived from PD patients with the VPS35-D620N mutation. Our findings reveal significant impairment in neurogen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11e1e73d-59c5-5cb3-a70e-ab12f7a13a67
DOI: 10.1101/2024.08.07.606995

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impaired neurogenesis and synaptogenesis in iPSC-derived Parkinson’s patient cortical neurons with D620N VPS35 mutationDOI 10.1101/2024.08.07.606995Read

Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson’s disease patientsSemantic proximity Read

Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models.Semantic proximity Read

Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson’s disease patientsSemantic proximity Read

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s diseaseSemantic proximity Read

Centrality of Early Synaptopathy in Parkinson’s DiseaseSemantic proximity Read

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based ModelsSemantic proximity Read

Synaptic dysfunction in Parkinson's disease.Semantic proximity Read

Modeling and targeting haploinsufficiency in SHINE syndromeSemantic proximity Read

iPSC-derived extracellular vesicles rescue deficits in human and mouse models of Parkinson’s diseaseSemantic proximity Read

Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.Semantic proximity Read

Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegenerationSemantic proximity Read

Synaptic vulnerability in neurodegenerative disease.Semantic proximity Read