Article

MicroRNAs alteration and unique distribution in the soma and synapses of substantia nigra in Parkinson’s disease

2025-03-13

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is the second most common neurodegenerative condition after Alzheimer’s. Abnormal accumulation of alpha-synuclein (α-syn) aggregates disrupts the balance of dopaminergic (DA-ergic) synapse components, interfering with dopamine transmission and leading to synaptic dysfunction and neuronal loss in PD. However exact molecular mechanism underlying DA-ergic neuronal cell loss...

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Literature Corpus work: 767d727d-1ddb-5251-bf51-8239f49312d3
DOI: 10.1101/2025.03.12.642888

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