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Article

Synaptic proteostasis in Parkinson's disease.

Current opinion in neurobiology - 1 Feb 2022

Nachman Eliana, Verstreken Patrik

Abstract excerpt

There are over 7 million people worldwide suffering from Parkinson's disease, and this number will double in the next decade. Causative mutations and risk variants in >20 genes that predominantly act at synapses have been linked to Parkinson's disease. Synaptic defects precede neuronal death. However, we are only now beginning to understand which molecular mechanisms contribute to this synaptic dysfunction. In...

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Identifiers

PMID: 34653835
DOI: 10.1016/j.conb.2021.09.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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